alanine aminotransferase elevation in obese infants and children: a marker of early onset non alcoholic fatty liver disease

نویسندگان

guido engelmann department of pediatrics, lukas hospital, neuss, germany; department of pediatrics, lukas hospital, preussen str 84, d-41464 neuss, germany. tel: +49-21318883500, fax: +49-21318883599

georg friedrich hoffmann department of pediatrics, university of heidelberg, heidelberg, germany

juergen grulich-henn department of pediatrics, university of heidelberg, heidelberg, germany

ulrike teufel department of pediatrics, university of heidelberg, heidelberg, germany

چکیده

conclusions elevation of liver enzymes appears in 29 % obese children in a tertiary care centre. absolute alanine aminotransferase levels are significantly higher in obese than in overweight children. even obese children with normal liver enzymes show signs of fatty liver disease as demonstrated by liver enzymes at the upper limit of normal. results elevated alanine aminotransferase was observed in 29% of children. 26 % of obese and 30 % of overweight children had liver enzyme elevations. obese children had significantly higher alanine aminotransferase levels than overweight children (0.9 vs. 0.7 times the upper limit of normal; p = 0.04). objectives we have prospectively analyzed liver enzymes in all overweight and obese children coming to our tertiary care centre. patients and methods in a prospective study 224 healthy, overweight or obese children aged 1 - 12 years were examined. body mass index-standard deviation score, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl-transpeptidase were measured. background elevated aminotransferases serve as surrogate markers of non-alcoholic fatty liver disease, a feature commonly associated with the metabolic syndrome. studies on the prevalence of fatty liver disease in obese children comprise small patient samples or focus on those patients with liver enzyme elevation.

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hepatitis monthly

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